Antidote Used In The Treatment Of Poisoning By Organophosphorus Compounds Which Inhibit The Enzyme CholinesteraseBy Phosphorylation. Pralidoxime Acts By Reactivating This Enzyme And Thus Restores The Enzymatic Destruction Of Acetylcholine At The Neuromuscular Junction.

Nitriate Is A Short-acting Hypotensive Agent With A Duration Of Action Of 1 to 10 Minutes. It Produces Peripheral Vasodilatation And Reduces Peripheral Resistance By A Direct Action On Both Veins And Arterioles. Its Effect Appear Within A few Seconds Of IV Infusion And The Blood Pressure Should Be Monitored Closely During Administration. Sodium Nitroprusside Is Converted In The Erythrocytes To Cyanide Which Is Metabolised In The Liver To Thiocyanate by the Enzyme Rhodanase In The Presence Of Thiosulphate And Slowly Excreted In The Urine. The Plasma Half - Life Of Thiocyanate Is To Be About 3 to 7 Days And thiocyanate Can Accumulate To Toxic Concentrations If High Doses Of Sodium Nitroprusside Are Given For More Than 3 Days